Ayelet Fishman Lab

Laboratory of Molecular and Applied Biocatalysis

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Tyrosinase, a ubiquitous enzyme in all domains of life, performs two successive oxidation reactions: conversion of monophenols to diphenols, and oxidation of diphenols to quinones, subsequently turning them into melanin. Our group solved the structure of a bacterial tyrosinase in the presence of the monophenol tyrosine, and the diphenol L-Dopa. The structures prove unequivocally that all of the substrates are stabilized in the same orientation at the active site of the enzyme, and are positioned towards the same copper ion, unlike previous assumptions.

Posted on 01/12/201501/12/2015 Full size 1024 × 168

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Ayelet Fishman
Professor
Harry Oppenheimer Chair in Engineering
Department of Biotechnology and Food Engineering

afishman@technion.ac.il

Tel: 972-73-378-5898

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